Combining CRISPR-based gene perturbation with immunofluorescence and single-molecule RNA fluorescence in situ hybridisation allows precise quantification of the relationship between protein abundance and target gene expression at the single-cell level, over large cell populations. Image taken by Scott Berry (2019).
Research in biomedicine
«The biggest challenge of our era is to connect the biological scales. To delineate the rules by which interactions at a lower scale give rise to new properties in form and function at a higher scale, and how that feeds back on each other.» Lucas Pelkmans
